Niacinamide
Vitamin B3 supports several functions relevant to pigmentation-prone skin.
It helps support the skin barrier while reducing the visible transfer and accumulation of pigment within the upper skin layers, contributing to a more even-looking complexion.
Kojic-Based Depigmenting Technology
Kojic technology is used within cosmelan® formulations to help regulate tyrosinase activity, an enzyme involved in melanin production.
This contributes to the formula's pigment-correcting and regulatory action.
Rumex Occidentalis Extract
A botanical ingredient used in pigmentation-focused formulations to support a brighter, more even-looking complexion and complement other melanin-regulating actives.
Liquorice Root Extract
Glycyrrhiza Glabra Root Extract provides complementary brightening, antioxidant and soothing support, particularly useful when pigmentation occurs alongside inflammation or skin stress.
Vitamin C System
Vitamin C and its derivatives provide antioxidant support while helping promote a brighter and more even-looking complexion.
They also help defend against oxidative stress that can contribute to uneven pigmentation and premature visible ageing.
Vitamin A Derivatives
Vitamin A technology supports skin renewal and helps improve texture and tone as part of the broader corrective action of cosmelan® 2.
Phytic Acid
A multifunctional antioxidant and chelating ingredient used to support more even-looking pigmentation while complementing the formula's wider depigmenting system.
Soothing Support
Ingredients including Bisabolol and Allantoin provide complementary calming support within this highly corrective formulation.

Full Ingredient List:
Aqua, Caprylic/Capric Triglyceride, Azelaic Acid, Aloe Barbadensis Leaf Juice, Sodium Ascorbyl Phosphate, Titanium Dioxide, Glycerin, Kojic Acid, Poloxamer 407, Glyceryl Stearate, Ethoxydiglycol, Hydroxypropyl Starch Phosphate, Alpha-Arbutin, Butylene Glycol Dicaprylate/Dicaprate, Cyclomethicone, Ethylhexyl Methoxycinnamate, Niacinamide, Di-C12-13 Alkyl Malate, Ceteareth-25, PEG-8 Beeswax, Stearic Acid, Tocopheryl Acetate, Retinyl Palmitate, Dimethicone, Alcohol, Behenyl Alcohol, Disodium Ethylene Dicocamide PEG-15 Disulfate, Citric Acid, Ascorbic Acid, Bisabolol, Salicylic Acid, Sclerotium Gum, Sorbitan Stearate, Stearyl Dimethicone, Sodium Lauroyl Lactylate, Aminoethylphosphinic Acid, Rumex Occidentalis Extract, Acacia Senegal Gum, Glyceryl Stearate Citrate, Glycyrrhiza Glabra Root Extract, Allantoin, Sodium Metabisulfite, Butylene Glycol, Phytic Acid, Xanthan Gum, Phenoxyethanol, Manganese Oxide, Tocopherol.

Use only according to the application schedule prescribed by your skincare professional.
Mesoestetic South Africa currently lists cosmelan® 2 for morning and evening use, but specifically notes that frequency may vary according to the stage of the cosmelan® treatment.
Apply an even layer to clean, dry skin over the treatment area as prescribed.
Allow the product to absorb before applying your recommended recovery moisturiser.
During the day, finish with very high broad-spectrum photoprotection and reapply sunscreen as required.
Do not increase the frequency or quantity in an attempt to accelerate results.

The use of other products with Cosmelan 2 is not recommended.
Please avoid using this product if you have a known sensitivity or allergy to any of the active ingredients. Additionally, refrain from using it if you have sensitive skin, open wounds, or active infections. It is also not recommended for use during pregnancy or lactation.

Melasma
Post-inflammatory hyperpigmentation (PIH)
Post-acne dark marks
Sun-related pigmentation
Solar lentigines and uneven pigmentation
Persistent or recurrent facial dark spots of melanic origin
Uneven-looking skin tone
Clients completing the professional cosmelan® method
Clients requiring ongoing pigment regulation after professional treatment
All skin types and phototypes when professionally prescribed