RetinSphere® Technology
A retinoid technology designed to stimulate the skin's natural epidermal renewal process while supporting improved treatment tolerance.
The South African Endocare formulation information specifies 0.02% Retinol encapsulated in glycospheres together with Hydroxypinacolone Retinoate, helping the skin adjust progressively to retinoid use.
This makes Renewal Comfort Cream particularly useful as an introductory retinoid treatment or as supportive care within a more advanced renewal routine.
EDAFENCE® Technology
A patented technology developed to help protect the skin against environmental and external aggressors while supporting and strengthening the skin barrier.
EDAFENCE® is based around Deschampsia antarctica extract, an antioxidant-rich botanical technology used within Cantabria Labs formulations.
Niacinamide
A multifunctional form of Vitamin B3 that helps support the skin barrier, improve hydration and promote a more even, healthy-looking complexion.
Its barrier-supporting properties make it particularly useful in a formula containing retinoids.
Cross-Linked Hyaluronic Acid
Provides long-lasting hydration and helps support a smoother, more comfortable and hydrated skin appearance.
Its cross-linked structure is designed to provide sustained moisturising support.
Bisabolol
A soothing ingredient that helps calm and comfort sensitised or reactive-feeling skin.
Dipotassium Glycyrrhizate
A liquorice-derived soothing ingredient that provides additional calming support.
3-O-Ethyl Ascorbic Acid
A stable Vitamin C derivative that provides complementary antioxidant support.
Vitamin E
Provides additional antioxidant support and helps defend against oxidative stress.

Apply in the evening to clean, dry skin on the face and neck.
Use after lighter serums and treatment products where appropriate.
If you are new to retinoids or have sensitive skin, introduce gradually according to your skin's tolerance or the recommendation of your skincare professional.
If persistent irritation occurs, reduce the frequency of application or discontinue use.
Avoid direct contact with the eyes and mucous membranes.
Complete your daytime routine with a broad-spectrum SPF 50+ and avoid unnecessary direct sun exposure.

External use only.
Avoid direct contact with eyes.
May have slight stinging and flaking with the first few applications.
Avoid sun exposure or use photoprotection

All skin types
First-time retinoid users
Skin not yet accustomed to retinoids
Sensitive or sensitised skin
Dry or dehydrated skin
Fine lines and wrinkles
Uneven or rough skin texture
Skin requiring additional barrier support
Clients introducing an anti-ageing routine
Supporting more intensive retinoid routines
Skin requiring comfort alongside rejuvenating treatments